Statistical design and evaluation of a propranolol HCl gastric floating tablet

formulation and in vitro evaluation of ketoprofen gastric floating tablet

Formulation and Development of Modified Propranolol Hcl Tablet

A co-processed excipient was prepared from Tamarind seed polysaccharide (TSP) and mannitol in using direct compression as well as wet and dry granulation. The effect of the ratio of the two components, percentage of lubricant and particle size on the properties of the prepared co-processed excipient has been investigated. Optimal physicochemical properties of the excipient, from a manufacturing...

Design and in vitro evaluation of effervescent gastric floating drug delivery systems of propanolol HCl.

Abstract. The purpose of this research was to develop and evaluate effervescent gastric floating tablets of propranolol HCl. The oral delivery of antihypertensive propranolol HCl was facilitated by preparing an effervescent floating dosage form which could increase its absorption in the stomach by increasing the drug's gastric residence time. In the present work, effervescent floating tablets w...

Thermal sintering: a novel technique in the design of gastroretentive floating tablets of propranolol HCl and its evaluation.

The aim of the present investigation was to formulate thermally sintered floating tablets of propranolol HCl, and to study the effect of sintering conditions on drug release, as well as their in vitro buoyancy properties. A hydrophilic polymer, polyethylene oxide, was selected as a sintered polymer to retard the drug release. The formulations were prepared by a direct compression method and wer...

Design and In-vitro Evaluation of Sustained Release Floating Tablets of Metformin HCl Based on Effervescence and Swelling

An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...